mGWAS-Explorer

Metabolites

Connect metabolites to SNPs, genes or diseases

SNPs

Connect SNPs to genes, metabolites or diseases

Genes

Connect genes to SNPs, metabolites or diseases

MR Analysis

Perform Mendelian Randomization analysis

Search

Search individual SNPs or metabolites

News & Updates

Please reach us via our OmicsForum to ask questions related to mGWAS-Explorer;
Added a tutorial for two-sample Mendelian randomization analysis module (12/06/2022);
Added support to customize the graphics output (11/14/2022);
Added support for two-sample Mendelian randomization (11/04/2022);
Improved homepage design (10/19/2022);
Use the Resources (at top menu) to access the mGWAS studies (previous "Browse" module) (10/15/2022);
Added Download page to support downloading result tables and images; (10/11/2022);
Added Rasa chatbot; (10/09/2022);
Upgraded to Prime Faces 12.0.0; (10/08/2022);
Code cleaning and refactoring for better performance (09/26/2022);
Added support for auto-complete in search box (09/19/2022);
Added support to search both SNPs and/or metabolties (08/30/2022);

Main Features

Comprehensive Libraries

Comprehensive collection and deep annotation of results from 65 mGWAS publications. Integrated with HaploReg, VEP, KEGG, Transporter Classification Database (TCDB), Recon3D as well as common PPI databases.

Functional Insights

Create and visually explore SNP-based, gene-based, or metabolite-based networks. Perform SNP set enrichment analysis, gene set enrichment analysis, or metabolite set enrichment analysis.

Causal Inference

Leverage known diseases associated with SNPs, genes or metabolites to perform cross-phenotype association analysis or causal inference based on two sample Mendelian randomization.

Acknowledgements

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