Browse mGWAS Studies
IDBiofluidStudyPublicationSample SizePopulationGenotyping PlatformMetabolomics PlatformCutoff ThresholdBrowse
65bBloodViñuela_medRxiv_2021_targetedGenetic analysis of blood molecular phenotypes reveals regulatory networks affecting complex traits: a DIRECT study3029EuropeanIllumina HumanCore array (HCE24 v1.0)BIOCRATES (AbsoluteIDQ™ p150 kit)5e-08
65aBloodViñuela_medRxiv_2021_untargetedGenetic analysis of blood molecular phenotypes reveals regulatory networks affecting complex traits: a DIRECT study3029EuropeanIllumina HumanCore array (HCE24 v1.0)Metabolon (LC-MS/MS)5e-08
64BloodQin_medRxiv_2020Genome-wide association and Mendelian randomization analysis prioritizes bioactive metabolites with putative causal effects on common diseases8738EuropeanIllumina genome-wide SNP arrays (HumanCoreExome BeadChip, Human610-Quad BeadChip and HumanOmniExpress)Thermo Q Exactive Orbitrap4.5e-12
63BloodBorges_UKBB_2020Metabolic biomarkers in the UK Biobank measured by Nightingale Health 2020500000EuropeanAffymetrix genome-wide genotyping arrayNightingale NMR5e-08
62BloodMontasser_bioRxiv_2021Leveraging a founder population to identify novel rare-population genetic determinants of lipidome650Old Order Amish founder populationAffymetrix 500K arrayAgilent (6550 Q-TOF LC/MS)5e-08
61MitochondriaAboulmaouahib_HMG_2021First mitochondrial genome wide association study with metabolomics2718EuropeanIllumina MiSeqBIOCRATES (AbsoluteIDQ™ p150 kit)1e-05
60BloodHarshfield_BM_2021Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci13814+5662European+South AsianIllumina 660-Quad, Illumina HumanOmniExpress, AffymetrixThermo Q Exactive Orbitrap8.9e-10
59BloodLuo_KI_2021Genome-wide association study of serum metabolites in the African American Study of Kidney Disease and Hypertension619African AmericanIllumina Infinium Multi-Ethnic Global BeadChip arrayMetabolon HD41e-10
58BloodWang_CTM_2021Genome-wide association study of metabolites in patients with coronary artery disease identified novel metabolite quantitative trait loci1028+523Han ChineseIllumina Infinium GSA-24 v1.0 bead chipSCIEX (QTRAP 6500 LC-MS/MS)2.57e-10
57UrineCheng_NC_2021Rare genetic variants affecting urine metabolite levels link population variation to inborn errors of metabolism4864EuropeanIllumina Omni2.5Exome BeadChip arraysThermo Q Exactive Orbitrap2e-06
56CSFPanyard_CB_2021Cerebrospinal fluid metabolomics identifies 19 brain-related phenotype associations689EuropeanIllumina HumanOmniExpress-12v1_A, Infinium HumanOmniExpressExome-8 v1-2a, and Infinium Global Screening Array v1-0 BeadChipMetabolon UPLC-MS/MS5e-08
55BloodFeofanova_AJHG_2020A Genome-wide Association Study Discovers 46 Loci of the Human Metabolome in the Hispanic Community Health Study/Study of Latinos3926+1509European+HispanicIllumina Omni 2.5M array (HumanOmni2.5-8v1-1)Metabolon HD45e-08
54BloodLotta_NG_2021A cross-platform approach identifies genetic regulators of human metabolism and health30138EuropeanAffymetrix Axiom or Affymetrix SNP5.0 genotyping arrayBIOCRATES (AbsoluteIDQ™ p180, p150 kit), Metabolon HD4, Nightingale NMR4.9e-10
53SalivaNag_HMG_2020Genome-wide scan identifies novel genetic loci regulating salivary metabolite levels1419+1000EuropeanIllumina: 300K Duo and HumanHap610-Quad arraysMetabolon UPLC-MS1e-10
52UrineSchlosser_NG_2020Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans1221 + 406EuropeanIllumina Omni2.5Exome BeadChip arrayMetabolon UPLC–MS/MS4.3e-11
51Bloodde_Oliveira_Otto_PO_2018Genome-wide association meta-analysis of circulating odd-numbered chain saturated fatty acids: Results from the CHARGE Consortium11494EuropeanAffymetrix 6.0, Illumina 370, Illumina 550k, 610Q, 660Q, Affymetrix 6.0, Illumina OmniExpress and CardioMetabochipgas chromatography5e-08
50BloodKalsbeek_PO_2018A genome-wide association study of red-blood cell fatty acids and ratios incorporating dietary covariates: Framingham Heart Study Offspring Cohort2374EuropeanAffymetrix 500K and a 50K Human Gene Focused Panel arraygas chromatography5e-08
49BloodFeofanova_G_2018Sequence-Based Analysis of Lipid-Related Metabolites in a Multiethnic Study1872+1552European +African AmericanWES: Illumina GAII or HiSeq; WGS: Illumina Hisequation 2000Metabolon (GC/LC-MS)5e-08
48BloodTeslovich_HMG_2018Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study8545+2591EuropeanIllumina HumanOmniExpresss-12v1_C BeadChip (OmniExpress) and Infinium HumanExome-12 v1.0 BeadChip (Exome Chip)NMR5e-08
47BloodYousri_NC_2018Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population614+382QatariIllumina HiSeq 2000 exome sequencingMetabolon HD41.4e-07
46BloodDavis_PG_2017Common, low- frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study8372EuropeanIllumina HumanOmniExpress-12v1_C BeadChip and Infinium HumanExome-12 v1.0 BeadChipNMR5e-08
45Bloodde_Vries_HMG_2017Whole-genome sequencing study of serum peptide levels: the Atherosclerosis Risk in Communities study1552+1872European + African AmericansIllumina Hiseq 2000 whole genome sequencingMetabolon4.2e-10
44BloodHu_JLR_2017Discovery and fine-mapping of loci associated with MUFAs through trans-ethnic meta-analysis in Chinese and European populations3521+12020European + ChineseIllumina 370, 550, and 660W genotyping array, Affymetrix 6.0 genotyping arraygas chromatography5e-08
43BloodLong_NG_2017A. Whole- genome sequencing identifies common-to-rare variants associated with human blood metabolites1960EuropeanIllumina HiSeqX whole genome sequencingMetabolon (RP)/UPLC–MS/MS, HILIC/UPLC–MS/MS, Orbitrap mass analyzer5e-08
42BloodLotta_PM_2016Genetic Predisposition to an Impaired Metabolism of the Branched- Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis16596EuropeanAffymetrix Genome-Wide Human SNP Array 5.0, Affymetrix UK Biobank Axiom Array, Illumina 660w quad, Illumina CoreExome chipBIOCRATES (AbsoluteIDQ™ p180 kit), Metabolon DiscoveryHD45e-08
41BloodYu_GB_2016Whole genome sequence analysis of serum amino acid levels1872+1552European +African AmericanIllumina GAII or HiSeq exome sequencing+Illumina Hiseq 2000 whole genome sequencingMetabolon (GC-MS and LC-MS)5e-08
40BloodCornelis_HMG_2016Genome-wide association study of caffeine metabolites provides new insights to caffeine metabolism and dietary caffeine-consumption behavior9876EuropeanIllumina GWAS arrays, Illumina Metabochip arrayUPLC-MS/MS, UPLC-ESI-MS/MS5e-08
39BloodRhee_NC_2016An exome array study of the plasma metabolome2076+1528EuropeanIllumina HumanExome BeadChipAB SCIEX (5500 QTRAP triple quadrupole), Metabolon (GC-MS and LC-MS)5e-08
38BloodFall_D_2016Non- targeted metabolomics combined with genetic analyses identifies bile acid synthesis and phospholipid metabolism as being associated with incident type 2 diabetes1138+970+1630EuropeanSNP&SEQ genome-wide genotyping arraynon-targeted UPLC-MS5e-08
37BloodYazdani_GE_2016Identification of Rare Variants in Metabolites of the Carnitine Pathway by Whole Genome Sequencing Analysis1456EuropeanIllumina whole genome sequencingGC-MS and LC-MS5e-08
36BloodYet_PO_2016Genetic Influences on Metabolite Levels: A Comparison across Metabolomic Platforms1001EuropeanIllumina arrays (HumanHap300, HumanHap610Q, 1M-Duo and 1.2MDuo)BIOCRATES (AbsoluteIDQ™ p150 kit), Metabolon5e-08
35BloodKettunen_NC_2016Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA24925EuropeanGenome-wide genotyping array (Affymetrix, Illumina, Perlegen)NMR5e-08
34BloodHartiala_NC_2016Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease1985+1895+400EuropeanAffymetrix Genome-Wide Human Array 6.0 chipABI SCIEX QTRAP 55005e-08
33BloodHu_HMG_2016Genome-wide meta-analyses identify novel loci associated with n-3 and n-6 polyunsaturated fatty acid levels in Chinese and European-ancestry populations2685+656+8866+8962EuropeanIllumina Human660W and Affymetrix 6.0 genotyping arrayAgilent 6890 gas chromatography5e-08
32BloodKraus_PG_2015Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis1490+2022AmericanIllumina Human Omni1-Quad Infinium Bead ChipMS3e-07
31BloodBurkhardt_PG_2015Integration of Genome-Wide SNP Data and Gene-Expression Profiles Reveals Six Novel Loci and Regulatory Mechanisms for Amino Acids and Acylcarnitines in Whole Blood2107EuropeanAffymetrix Axiom SNP arrayApplied Biosystems API 2000 LC-MS/MS1e-07
30UrineRaffler_PG_2015Genome-Wide Association Study with Targeted and Non-targeted NMR Metabolomics Identifies 15 Novel Loci of Urinary Human Metabolic Individuality3861+1691EuropeanAffymetrix Human SNP Array 6.0 gene chipsBruker DRX-400 NMR3.25e-12
29BloodDraisma_NC_2015Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels7478+1182EuropeanGenome-wide genotyping array (Affymetrix, Illumina)BIOCRATES (AbsoluteIDQ™ p150 kit)5e-08
28BloodMozaffarian_AJCN_2014Genetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium8013European +African American + Chinese +HispanicIllumina HumanCNV370-Duo BeadChip, Illumina HumanOmni 1-Quad_v1 BeadChip, Illumina Infinium II assay, Affymetrix Genome-Wide Human SNP Array 6.0Agilent 5890 gas-chromatography5e-08
27BloodYu_CCG_2015Association of Rare Loss-Of-Function Alleles in HAL, Serum Histidine: Levels and Incident Coronary Heart Disease1152+718+753EuropeanIllumina Omni 5M, Roche Nimblegen’s VChrome2.1, Illumina HiSeq 2000 (exome)Metabolon LC-MS5e-08
26BloodDemirkan_PG_2015Insight in genome-wide association of metabolite quantitative traits by exome sequence analyses2118EuropeanIllumina Infinium HumanHap300v2, HumanHap300v1 or HumanCNV370v1 SNP bead microarrays, Illumina Hiseq2000 (exome)Bruker Avance II NMR5e-08
25BloodTintle_PLEFA_2014A genome-wide association study of saturated, mono- and polyunsaturated red blood cell fatty acids in the Framingham Heart Offspring Study2633EuropeanAffymetrix 500K and MIPS 50K chipsgas chromatography5e-08
24BloodLemaitre_JLR_2015Genetic loci associated with circulating levels of very long- chain saturated fatty acids10129EuropeanIllumina’s Infinium II assay, Illumina HumanCNV370-Duo BeadChip, Affymetrix 6.0gas chromatography5e-08
23BloodGuan_CCG_2014Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium8631EuropeanAffymetrix 6.0, Illumina 370, Illumina 550gas chromatography5e-08
22BloodShin_NG_2014An atlas of genetic influences on human blood metabolites7824EuropeanAffymetrix 6.0, Illumina arrays (HumanHap300, HumanHap610Q, 1M-Duo and 1.2MDuo)Metabolon GC-MS or UPLC-MS/MS5e-08
21BloodYu_PG_2014Genetic determinants influencing human serum metabolome among African Americans1260African AmericanAffymetrix 6.0Metabolon (GC-MS and LC-MS)1.6e-10
20UrineRueedi_PG_2014Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links835+601European + BrazilIllumina Human Omni-Quad1Bruker Avance II 700 MHz NMR5e-08
19BloodYu_GE_2013Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study1260AfricanAffymetrix 6.0Metabolon (GC-MS and LC-MS)5e-08
18BloodRhee_CM_2013A genome-wide association study of the human metabolome in a community-based cohort2076EuropeanAffymetrix 500K mapping array and Affymetrix 50K gene-focused MIP arrayAB SCIEX (5500 QTRAP triple quadrupole)5e-08
17BloodRaffler_GM_2013Identification and MS-assisted interpretation of genetically influenced NMR signals in human plasma1757EuropeanAffymetrix 6.0Bruker 600 MHz NMR, BIOCRATES (AbsoluteIDQ™ p150 kit), Metabolon (UHPLC/MS/MS and GC-MS)5e-08
16BloodXie_D_2013Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes1004+341EuropeanAffymetrix 6.0UHPLC-MS/MS5e-08
15BloodWu_CCG_2013Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium8961EuropeanAffymetrix 6.0, Illumina 370, Illumina 550gas chromatography5e-08
14BloodHong_HM_2013A genome-wide assessment of variability in human serum metabolism402+489EuropeanAffymetrix 500K and 5.0KUPLC–MS5e-08
13BloodKrumsiek_PG_2012Mining the unknown: a systems approach to metabolite identification combining genetic and metabolic information1768EuropeanAffymetrix 6.0Metabolon (MS)5e-08
12BloodInouye_PG_2012Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis1905+4703EuropeanIllumina 670 BeadArray and Illumina 370CNVduoNMR4.5e-09
11BloodDemirkan_PG_2012Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations4043EuropeanIllumina Infinium HumanHap300v2, HumanHap300v1, HumanCNV370v1 SNP bead microarraysESIMS/MS5e-08
10BloodKettunen_NG_2012Genome-wide association study identifies multiple loci influencing human serum metabolite levels8330EuropeanIllumina HumanHap 610kNMR5e-08
9BloodTukiainen_HMG_2012Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci8330EuropeanIllumina HumanHap CNV 370k, Illumina HumanHap 610k, Illumina HumanHap 670kNMR5e-08
8BloodNicholson_PG_2011A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection211EuropeanIllumina 317KBIOCRATES (AbsoluteIDQ™ p150 kit), Bruker DRX 600 MHz NMR5e-08
7BloodSuhre_N_2011Human metabolic individuality in biomedical and pharmaceutical research1768+1052EuropeanAffymetrix 6.0, Illumina (HumanHap300, HumanHap610Q, 1M-Duo and 1.2MDuo 1M)Metabolon (UHPLC/MS/MS2 and GC/MS)5e-08
6BloodLemaitre_PG_2011Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium8866EuropeanAffymetrix 6.0, Illumina 370, Illumina 550gas chromatography5e-08
5UrineSuhre_NG_2011A genome-wide association study of metabolic traits in human urine862EuropeanAffymetrix 6.0Bruker DRX-400 NMR4.5e-11
4BloodIllig_NG_2010A genome-wide perspective of genetic variation in human metabolism1809+422EuropeanAffymetrix 6.0, Illumina Hap317KBiocrates AbsoluteIDQ5e-08
3BloodHicks_PG_2009Genetic determinants of circulating sphingolipid concentrations in European populations4400EuropeanIllumina Infinium HumanHap300v2, HumanCNV370v1ESI-MS/MS5e-08
2BloodTanaka_PG_2009Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study1210+1076EuropeanIllumina Infinium HumanHap550gas chromatography5e-08
1BloodGieger_PG_2008Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum284EuropeanAffymetrix 500KBiocrates (ESI-MS/MS)5e-08
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